The dicyclohexylamine salt of RG108 (N-phthalyl-l-tryptophan), a potential epigenetic modulator
نویسندگان
چکیده
The dicyclo-hexyl-amine salt of RG108 (N-phthalyl-l-tryptophan) co-crystallizes with a water mol-ecule and a disordered mol-ecule of dimethyl-formamide (DMF), viz. dicyclo-hexyl-aminium (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoate dimethyl-formamide solvate monohydrate, C(12)H(24)N(+)·C(19)H(13)N(2)O(4) (-)·C(3)H(7)NO·H(2)O. The conformation of the deprotonated compound is constrained by charge-assisted strong hydrogen bonds with the dicyclo-hexyl-aminium ion and a dense hydrogen-bond network involving co-crystallized solvent mol-ecules. The dihedral angle between the fused ring systems in the anion is 58.35 (4)°.
منابع مشابه
4-Nitro-N-phthalyl-l-tryptophan
THE CRYSTAL STRUCTURE OF THE TITLE COMPOUND [SYSTEMATIC NAME: (2R)-3-(1H-indol-3-yl)-2-(4-nitro-1,3-dioxoisoindolin-2-yl)propanoic acid], C(19)H(13)N(3)O(6), an analogue of epigenetic modulator RG108, is constrained by strong hydrogen bonds between the indole N-H group and a carbonyl O atom of the phthalimide ring of a symmetry-related mol-ecule, and between the protonated O atom of the carboxy...
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